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Take this medication by mouth as directed by your doctorusually 3 times daily with the first bite of a mealThe dosage is based on your medical condition and response to treatmentTo reduce your risk of side effectsyour doctor may direct you to start this medication at a low dose and gradually increase your doseFollow your doctor’s instructions carefully.

The mean steady-state area under the curveAUCand maximum concentrations of acarbose were approximately 1.5 times higher in elderly compared to young volunteershoweverthese differences were not statistically significantPatients with severe renal impairmentClcr Table 1 Mean Placebo-Subtracted Change in HbA1c in Fixed-Dose Monotherapy Studies.

Acarbose did not induce any DNA damage in vitro in the CHO chromosomal aberration assaybacterial mutagenesisAmesassayor a DNA binding assayIn vivono DNA damage was detected in the dominant lethal test in male miceor the mouse micronucleus test.

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